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  1. Townsend N. et al. (2016) Cardiovascular disease in Europe: epidemiological update 2016. Eur Heart J, published online ahead of print.
  2. European Heart Network, ‘European Cardiovascular Disease Statistics 2012’. Available at:
  3. Petersen S. (2005) European cardiovascular disease statistics. BHF: London.
  4. van Dam R. (2008) Combined impact of lifestyle factors on mortality: prospective cohort study in US women. BMJ, 337:a1440.
  5. Mozaffarian D. et al. (2008) Beyond established and novel risk factors: lifestyle risk factors for cardiovascular disease. Circ, 117(23):3031-8.
  6. Mostofsky E. et al. (2012) Habitual coffee consumption and risk of heart failure: a dose-response meta-analysis. Circ Heart Fail, 5(4):401–405.
  7. Malerba S. et al. (2013) A meta-analysis of prospective studies of coffee consumption and mortality for all causes, cancers and cardiovascular diseases. Eur J Epidemiol, 28(7):527-39.
  8. Liu J. et al. (2013) Association of Coffee Consumption with All-Cause and Cardiovascular Disease Mortality. Mayo Clinic Proc, 88:10.
  9. Rebello S.A. and van Dam R.M. (2013) Coffee Consumption and Cardiovascular Health: Getting to the Heart of the Matter. Curr Cardiol Reps, 15:403.
  10. Ding M. et al (2014) Long-term coffee consumption and risk of cardiovascular disease: a systematic review and a dose-response meta-analysis of prospective cohort studies. Circ, 129(6):643-59.
  11. Crippa A. et al. (2014) Coffee consumption and mortality from all causes, cardiovascular disease, and cancer: a dose-response meta-analysis. Am J Epidemiol, 180(8):763-75.
  12. Wu J. et al. (2009) Coffee consumption and the risk of coronary heart disease: a meta-analysis of 21 prospective cohort studies. Int J Cardiol, 137:216-225.
  13. Sugiyama K. et al. (2010) Coffee consumption and mortality due to all causes, cardiovascular disease, and cancer in Japanese women. J Nur, 140(5):1007-1013.
  14. de Koning Gans J.M. et al. (2010) Tea and coffee consumption and cardiovascular morbidity and mortality. Arterioscler Thromb Vasc Biol, 30:1665-1671.
  15. Ahmed H.N. et al. (2009) Coffee consumption and risk of heart failure in men: an analysis from the cohort of Swedish men. Am Heart J, 158:667-672.
  16. Nilson L.M. et al. (2009) Consumption of filtered and boiled coffee and the risk of first acute myocardial infarction: a nested case/referent study. Nutr Metabol & Cardiovasc Dis, 20(7):527-535.
  17. Larrson S.C. and Orsini N. (2011) Coffee consumption and risk of stroke: A dose-response meta-analysis of prospective studies, Am J Epidemiol, 174(9):993-100.
  18. Kim B. et al. (2012) Coffee consumption and stroke risk: A meta-analysis of epidemiologic studies. Korean J Fam Med, 33(6):356-65.
  19. Lopez-Garcia E. et al. (2009) Coffee consumption and risk of stroke in women. Circ, 119:1116-1123.
  20. Leurs L.J. et al. (2010) Total fluid and specific beverage intake and mortality due to ID and stroke in the Netherlands cohort study. Br J Nutr, 104:1212-1221.
  21. Lutsey P.L. et al. (2009) Dietary intake and the development of the metabolic syndrome. The Atherosclerosis Risk in Communities Study. Am Heart J, 157:1081-1087.
  22. Liebeskind D.S. et al. (2015) The coffee paradox in stroke: increased consumption linked to fewer strokes. Nutr Neurosci, 22:1476– 8305.
  23. Kokubo Y. et al. (2013) The Impact of Green Tea and Coffee Consumption on the Reduced Risk of Stroke Incidence in Japanese Population: The Japan Public Health Center-Based Study Cohort. Stroke, 44(5):1369-74.
  24. Cheng M. et al. (2014) Caffeine Intake and Atrial Fibrillation Incidence: Dose Response Meta-analysis of Prospective Cohort Studies. Can J Cardiol, 30(4):448-54.
  25. Caldeira D. et al. (2013) Caffeine does not increase the risk of atrial fibrillation: a systematic review and meta-analysis of observational studies. Heart, 99:1383-1389.
  26. Mostofsky E. et al. (2015) Risk of Atrial Fibrilation Associated with Coffee Intake: Findings from the Danish Diet, Cancer, and Health Study. Eur J Prev Cardiol, 23(9):922-930.
  27. Larsson S.C. et al, 2015. Coffee consumption is not associated with increased risk of atrial fibrillation: results from two prospective cohorts and a meta-analysis. BMC Medicine, 13(1):207.
  28. Conen D. et al. (2010) Caffeine consumption and incident atrial fibrillation in women. AJCN, 92(3):509-14.
  29. Frost L. and Vestergaard P. (2005) Caffeine and risk of atrial fibrillation or flutter: the Danish Diet, Cancer and Health Study. AJCN, 81:578-582.
  30. Geleijnse J.M. (2008) Habitual coffee consumption and blood pressure: An epidemiological perspective. Vasc Health Risk Man, 4(5):963-970.
  31. Mesas A.E. et al. (2011) The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis. AJCN, 94(4):1113-26.
  32. Zhang Z. et al. (2011) Habitual coffee consumption and risk of hypertension: a systematic review and meta-analysis of prospective observational studies. AJCN, 93(6):1212-9.
  33. Rhee J.J. et al. (2016) Coffee and Caffeine Consumption and the Risk of Hypertension in Postmenopausal Women. AJCN, 103(1):210-7.
  34. Renda G. et al. (2012) Genetic determinants of blood pressure responses to caffeine drinking. AJCN, 95(1):241-248
  35. Urgert R. and Katan M.B. (1996) The cholesterol-raising factor from coffee beans. J R Med, 89(11):618-623.
  36. Jee S.H. et al. (2001) Coffee consumption and serum lipids: a meta-analysis of randomized controlled clinical trials. Am J Epidemiol, 153: 353-362.
  37. Nystad T. et al. (2010) The effect of coffee consumption on serum total cholesterol in the Sami & Norwegian populations. Public Health Nutrition, 13(11):1818-1825.
  38. Correa T.A.F. et al. (2013) Paper filtered coffee increases cholesterol and inflammation biomarkers independent of roasting degree. Nutrition, 29:977-981.
  39. Grioni S. et al. (2015) Espresso coffee consumption and risk of coronary heart disease in a large Italian cohort. PLoS One, 6;10(5):e0126550.
  40. Buscemi S. et al. (2010) Acute effects of coffee on endothelial function in healthy subjects. Eur J Clin Nutr, 64(5):483-489.
  41. Buscemi S. et al. (2010) Coffee and endothelial function: a battle between caffeine and antioxidants. Eur J Clin Nutr, 64:1242-1243.
  42. Aqudelo-Ochoa G.M. (2016) Coffee consumption increases the antioxidant capacity of plasma and has no effect on the lipid profile or vascular function in healthy adults in a randomized controlled trial. J Nutr, 146(3):524-531.
  43. Refsum H. et al. (2006) The Hordaland Homocysteine Study: a community based study of homocysteine, its determinants, and associations with disease. J Nutr, 136 (6suppl):17731S-1740S.
  44. Henkey G.J. and Eikelboom J.W. (1999) Homocysteine and Vascular Disease. Lancet, 354:407-413.
  45. Folsom A.R. et al. (1998) Prospective study of coronary heart disease incidence in relation to fasting homocysteine, related polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study. Circulation, 98:204-210.
  46. Fallon U.B. et al. (2001) Homocysteine and coronary heart disease in the Caerphilly cohort: a 10 year follow-up. Heart, 85:53-158.
  47. Higdon J.V. and Frei B. (2006) Coffee and Health: A Review of Recent Human Research. Crit Revs Fd Sci Nutr, 46:101-123.
  48. Grubben M.J. et al. (2000) Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: a randomized trial. AJCN, 71:448-484.
  49. Urgert R.A. et al. (2000) Heavy coffee consumption and plasma homocysteine: a randomized controlled trial in healthy volunteers. AJCN, 72:1107-1110.
  50. Christensen B. et al. (2001) Abstention from filtered coffee reduces concentrations of plasma homocysteine and serum cholesterol – a randomized controlled trial. AJCN, 74 (3):302-307.
  51. Espositio F. et al. (2003) Moderate coffee consumption increases plasma glutathione but not homocysteine in healthy subjects. Aliment Pharmacol Therapy, 17:595-601.
  52. Verhoef P. et al. (2002) Contribution of caffeine to the homocysteine-raising effect of coffee: a randomized controlled trial in humans. AJCN, 76:1244-1248.
  53. Olthof M.R. et al. (2001) Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans. AJCN, 7(737):532-538.
  54. Zhang W. et al. (2009) Coffee consumption and risk of cardiovascular disease and all-cause mortality among men with type 2 diabetes. Diabetes Care, 32:1043-1045.
  55. Mukanal K.J. et al. (2009) Coffee consumption and mortality after acute myocardial infarction: the Stockholm Heart Epidemiology Program. Am Heart J, 157:495-501.
  56. Palatini P. et al. (2009) CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension. J Hypertension, 27(8):1594-1601.
  57. Lopez-Garcia E. et al. (2016) Habitual coffee consumption and 24-hour blood pressure control in older adults with hypertension. Clin Nutr, published online ahead of print.
  58. Notara V. et al. (2015) The role of coffee consumption on the 10-year (2004 – 2014) Acute Coronary Syndrome (ACS) Incidence among cardiac patients: the GREECS observational study. Int J Fd Sci & Nutr, 66(6):722-8.
  59. Brown O.L. (2016) Coffee reduces the Risk of Death after Acute Myocardial Infarction: A Meta-Analysis. Coron Art Dis, published online ahead of print.
  60. Kastorini C-M. et al. (2009) Moderate coffee consumption lowers the likelihood of developing left ventricular systolic dysfunction in post-acute coronary syndrome normotensive patients. J Med Food, 12(1):29-36.
  61. Richardson T. et al. (2009) Randomized control trials investigating the influence of coffee on heart rate variability in patients with ST-segment elevation myocardial infarction. Q J Med, 102(8):555-561.
  62. Namdar M. et al. (2009) Caffeine impairs myocardial blood flow response to physical exercise in patients with artery disease as well as in age-matched controls. PloS ONE, 4(5):e5665, 2009.
  63. Shechter M. et al. (2011) Impact of acute caffeine ingestion on endothelial function in subjects with and without coronary artery disease. Am J Cardiol, 107(9):1255-61.
  64. Farag N.H. et al. (2010) Caffeine and blood pressure response, sex, age, and hormonal status. J Women’s Health, 19(6):1171-1176.

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