Overview

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  • Two major prospective cohort studies, looking at the relationship between coffee consumption and the development of gallbladder disease, consistently report clear and statistically significant inverse associations between coffee consumption and the risk of symptomatic gallstones*. Coffee consumption may have a beneficial effect.
  • Other studies, which do not observe direct associations between coffee consumption and gallbladder disease, do however provide relevant insights.
  • For example, a cross-sectional study suggests that coffee may have different effects depending on the stage of gallbladder disease progression.
  • There is some evidence that caffeine triggers the contraction of the gallbladder; however, more large trials are warranted to further explore the mechanisms behind the inverse association between coffee consumption and the development of gallbladder disease.

The content in this Topic Overview was last edited in November 2014. Papers in the Latest Research section and further resources are added regularly.

*Very few relevant, and significant, human epidemiological studies on the role of coffee in gallbladder disease have been published since 2002.

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